Reduced parietal connectivity with a premotor writing area in writer's cramp.
Identifieur interne : 000C38 ( Main/Exploration ); précédent : 000C37; suivant : 000C39Reduced parietal connectivity with a premotor writing area in writer's cramp.
Auteurs : Cathérine C S. Delnooz [Pays-Bas] ; Rick C. Helmich ; Ivan Toni ; Bart P C. Van De WarrenburgSource :
- Movement disorders : official journal of the Movement Disorder Society [ 1531-8257 ] ; 2012.
English descriptors
- KwdEn :
- Adult, Aged, Brain Mapping, Dystonia (physiopathology), Dystonic Disorders (pathology), Dystonic Disorders (physiopathology), Female, Functional Laterality (physiology), Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Middle Aged, Motor Cortex (blood supply), Motor Cortex (pathology), Neural Pathways (blood supply), Neural Pathways (pathology), Oxygen (blood), Parietal Lobe (blood supply), Parietal Lobe (pathology).
- MESH :
- chemical , blood : Oxygen.
- blood supply : Motor Cortex, Neural Pathways, Parietal Lobe.
- pathology : Dystonic Disorders, Motor Cortex, Neural Pathways, Parietal Lobe.
- physiology : Functional Laterality.
- physiopathology : Dystonia, Dystonic Disorders.
- Adult, Aged, Brain Mapping, Female, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Middle Aged.
Abstract
Writer's cramp is a task-specific form of dystonia with symptoms characterized by abnormal movements and postures of the hand and arm evident only during writing. Its pathophysiology has been related to faulty sensorimotor integration, abnormal sensory processing, and impaired motor planning. Its symptoms might appear when the computational load of writing pushes a tonically altered circuit outside its operational range. Using resting-state fMRI, we tested whether writer's cramp patients have altered intrinsic functional connectivity in the premotor-parietal circuit. Sixteen patients with right-sided writer's cramp and 19 control subjects were studied. We show that writer's cramp patients have reduced connectivity between the superior parietal lobule and a dorsal precentral region that controls writing movements. This difference between patients and controls occurred in the absence of writing and only in the hemisphere contralateral to the affected hand. This finding adds a novel element to the pathophysiological substrate for writer's cramp, namely, task-independent alterations within a writing-related circuit.
DOI: 10.1002/mds.25029
PubMed: 22886735
Affiliations:
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Le document en format XML
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Delnooz</name><affiliation wicri:level="3"><nlm:affiliation>Radboud University Nijmegen Medical Centre, Department of Neurology, Donders Institute for Brian, Cognition and Behaviour, Centre for Neuroscience, Nijmegen, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Radboud University Nijmegen Medical Centre, Department of Neurology, Donders Institute for Brian, Cognition and Behaviour, Centre for Neuroscience, Nijmegen</wicri:regionArea><placeName><settlement type="city">Nimègue</settlement><region type="province" nuts="2">Gueldre</region></placeName></affiliation></author><author><name sortKey="Helmich, Rick C" sort="Helmich, Rick C" uniqKey="Helmich R" first="Rick C" last="Helmich">Rick C. Helmich</name></author><author><name sortKey="Toni, Ivan" sort="Toni, Ivan" uniqKey="Toni I" first="Ivan" last="Toni">Ivan Toni</name></author><author><name sortKey="Van De Warrenburg, Bart P C" sort="Van De Warrenburg, Bart P C" uniqKey="Van De Warrenburg B" first="Bart P C" last="Van De Warrenburg">Bart P C. Van De Warrenburg</name></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2012">2012</date><idno type="doi">10.1002/mds.25029</idno><idno type="RBID">pubmed:22886735</idno><idno type="pmid">22886735</idno><idno type="wicri:Area/PubMed/Corpus">000C84</idno><idno type="wicri:Area/PubMed/Curation">000C84</idno><idno type="wicri:Area/PubMed/Checkpoint">000C56</idno><idno type="wicri:Area/Ncbi/Merge">003762</idno><idno type="wicri:Area/Ncbi/Curation">003762</idno><idno type="wicri:Area/Ncbi/Checkpoint">003762</idno><idno type="wicri:Area/Main/Merge">000C48</idno><idno type="wicri:Area/Main/Curation">000C38</idno><idno type="wicri:Area/Main/Exploration">000C38</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Reduced parietal connectivity with a premotor writing area in writer's cramp.</title><author><name sortKey="Delnooz, Catherine C S" sort="Delnooz, Catherine C S" uniqKey="Delnooz C" first="Cathérine C S" last="Delnooz">Cathérine C S. Delnooz</name><affiliation wicri:level="3"><nlm:affiliation>Radboud University Nijmegen Medical Centre, Department of Neurology, Donders Institute for Brian, Cognition and Behaviour, Centre for Neuroscience, Nijmegen, The Netherlands.</nlm:affiliation><country xml:lang="fr">Pays-Bas</country><wicri:regionArea>Radboud University Nijmegen Medical Centre, Department of Neurology, Donders Institute for Brian, Cognition and Behaviour, Centre for Neuroscience, Nijmegen</wicri:regionArea><placeName><settlement type="city">Nimègue</settlement><region type="province" nuts="2">Gueldre</region></placeName></affiliation></author><author><name sortKey="Helmich, Rick C" sort="Helmich, Rick C" uniqKey="Helmich R" first="Rick C" last="Helmich">Rick C. Helmich</name></author><author><name sortKey="Toni, Ivan" sort="Toni, Ivan" uniqKey="Toni I" first="Ivan" last="Toni">Ivan Toni</name></author><author><name sortKey="Van De Warrenburg, Bart P C" sort="Van De Warrenburg, Bart P C" uniqKey="Van De Warrenburg B" first="Bart P C" last="Van De Warrenburg">Bart P C. Van De Warrenburg</name></author></analytic><series><title level="j">Movement disorders : official journal of the Movement Disorder Society</title><idno type="eISSN">1531-8257</idno><imprint><date when="2012" type="published">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Brain Mapping</term><term>Dystonia (physiopathology)</term><term>Dystonic Disorders (pathology)</term><term>Dystonic Disorders (physiopathology)</term><term>Female</term><term>Functional Laterality (physiology)</term><term>Humans</term><term>Image Processing, Computer-Assisted</term><term>Magnetic Resonance Imaging</term><term>Male</term><term>Middle Aged</term><term>Motor Cortex (blood supply)</term><term>Motor Cortex (pathology)</term><term>Neural Pathways (blood supply)</term><term>Neural Pathways (pathology)</term><term>Oxygen (blood)</term><term>Parietal Lobe (blood supply)</term><term>Parietal Lobe (pathology)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Oxygen</term></keywords><keywords scheme="MESH" qualifier="blood supply" xml:lang="en"><term>Motor Cortex</term><term>Neural Pathways</term><term>Parietal Lobe</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Dystonic Disorders</term><term>Motor Cortex</term><term>Neural Pathways</term><term>Parietal Lobe</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Functional Laterality</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Dystonia</term><term>Dystonic Disorders</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Brain Mapping</term><term>Female</term><term>Humans</term><term>Image Processing, Computer-Assisted</term><term>Magnetic Resonance Imaging</term><term>Male</term><term>Middle Aged</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Writer's cramp is a task-specific form of dystonia with symptoms characterized by abnormal movements and postures of the hand and arm evident only during writing. Its pathophysiology has been related to faulty sensorimotor integration, abnormal sensory processing, and impaired motor planning. Its symptoms might appear when the computational load of writing pushes a tonically altered circuit outside its operational range. Using resting-state fMRI, we tested whether writer's cramp patients have altered intrinsic functional connectivity in the premotor-parietal circuit. Sixteen patients with right-sided writer's cramp and 19 control subjects were studied. We show that writer's cramp patients have reduced connectivity between the superior parietal lobule and a dorsal precentral region that controls writing movements. This difference between patients and controls occurred in the absence of writing and only in the hemisphere contralateral to the affected hand. This finding adds a novel element to the pathophysiological substrate for writer's cramp, namely, task-independent alterations within a writing-related circuit.</div></front></TEI><affiliations><list><country><li>Pays-Bas</li></country><region><li>Gueldre</li></region><settlement><li>Nimègue</li></settlement></list><tree><noCountry><name sortKey="Helmich, Rick C" sort="Helmich, Rick C" uniqKey="Helmich R" first="Rick C" last="Helmich">Rick C. Helmich</name><name sortKey="Toni, Ivan" sort="Toni, Ivan" uniqKey="Toni I" first="Ivan" last="Toni">Ivan Toni</name><name sortKey="Van De Warrenburg, Bart P C" sort="Van De Warrenburg, Bart P C" uniqKey="Van De Warrenburg B" first="Bart P C" last="Van De Warrenburg">Bart P C. Van De Warrenburg</name></noCountry><country name="Pays-Bas"><region name="Gueldre"><name sortKey="Delnooz, Catherine C S" sort="Delnooz, Catherine C S" uniqKey="Delnooz C" first="Cathérine C S" last="Delnooz">Cathérine C S. 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